Los Che will enter the contest off the back of a 2-2 draw with Barcelona at Camp Nou on Saturday, while Sevilla were held to a 1-1 draw by lowly Real Valladolid.
Valencia have had their fair share of problems this season, but Javi Gracia's team will enter this contest off the back of a positive result, having secured a point away to Barcelona on Saturday night.
Ronald Koeman's team turned the game around to lead 2-1 early in the second period, but Maxi Gomez struck in the 69th minute to secure a share of the spoils for Los Che, who currently sit 12th in the table, having picked up 15 points from their 14 league games this term.
The fact that Valencia have only won three of their 14 La Liga matches this season is a concern, while they have suffered five defeats, with Celta Vigo, Real Betis, Villarreal, Elche and Atletico Madrid all beating them in 2020-21.
Gracia's side managed to progress to the second round of the Copa del Rey courtesy of a 4-2 victory over Terrassa last week, though, and they will be looking to end the year with back-to-back victories over Sevilla and Granada, which is likely to leave them in a healthier position heading into 2021.
Sevilla, meanwhile, were held to a 1-1 draw by Valladolid on Saturday; Lucas Ocampos sent the hosts ahead in the 31st minute from the penalty spot, but Raul Garcia levelled in the latter stages of the contest.
A record of six wins, two draws and four defeats has seen Julen Lopetegui's side collect 20 points, leaving them in sixth position in the table, five points off fourth-placed Villarreal with two games in hand.
Los Nervionenses have booked their spot in the knockout stage of the Champions League, while they have advanced to the second round of the Copa del Rey courtesy of a 3-0 win over Ciudad de Lucena.
Sevilla's European involvement means that they have played a lot of football this season, and it is a tough end to the year for the club as they face Valencia and Villarreal in back-to-back fixtures.
The Europa League holders recorded a 1-0 victory over Valencia when the two teams last locked horns in July, but the corresponding clash last term finished in a 1-1 draw.
Valencia La Liga form: WDLDDD
Valencia form (all competitions): DLDDWD
Sevilla La Liga form: WWWLWD
Sevilla form (all competitions): LLWWWD
The bulk of the XI that started against Barca are again expected to take to the field for this game, although there could be a change in the final third with Manu Vallejo potentially coming in for Goncalo Guedes.
Valencia possible starting lineup:
Domenech; Wass, Paulista, Diakhaby, Gaya; Blanco, Soler, Racic, Guedes; Gomez, Vallejo
Sevilla possible starting lineup:
Bounou; Navas, Kounde, Carlos, Acuna; Rakitic, Fernando, Jordan; Ocampos, De Jong, Suso
We say: Valencia 1-1 Sevilla
Valencia have drawn four of their last five in the league and have lost just one of their last seven; Sevilla will be eyeing an important three points, but we are finding it difficult to separate the two sides here, ultimately backing a low-scoring draw at Mestalla.