While the home side look certainties for relegation, Preston sit in 15th position after claiming just one victory in six fixtures.
Sitting 12 points adrift of 21st place with just 11 matches remaining, Gareth Ainsworth knows that his Wycombe side are running out of chances to stay in the second tier.
Despite their tough recent schedule, Ainsworth will be desperately disappointed that four successive defeats have occurred without them troubling the scoresheet.
The Chairboys remained in the games at Stoke City and Queens Park Rangers for long periods, but failure to breach either backline means that last season's League One playoff winners are almost at the point of no return.
Just 14 points and 10 goals have come from their 17 home encounters, statistics which will be viewed as the difference makers if Wycombe's relegation is confirmed in the coming weeks.
Nevertheless, while they can mathematically survive, Ainsworth will have faith in a group of players which have occasionally produced against the odds this season.
Like their hosts, Preston will regard this fixture as the ideal opportunity to get back on track after going two matches without a win.
With just one point being claimed from meetings with Millwall and Bournemouth, Alex Neil's side look increasingly likely to remain in mid-table for the rest of the season.
However, still trailing 11th position by just two points, there is an opportunity for Preston to get themselves back into the top half of the table with a ninth away success of the season.
Only leaders Norwich City have won more games on their travels, suggesting that the North-West outfit have the quality in their ranks to make a late burst for the top eight.
Despite having recently returned to the substitutes' bench, Adebayo Akinfenwa is unlikely to be used in the starting lineup.
Wycombe Wanderers possible starting lineup:
Stockdale; McCarthy, Knight, Tafazolli, Jacobson; Ofoborh, Gape; Kashket, Mehmeti, Horgan; Ikpeazu
Preston North End possible starting lineup:
Iversen; Van den Berg, Huntington, Storey, Cunningham; Browne, Whiteman; Barkhuizen, Johnson, Gordon; Evans
We say: Wycombe Wanderers 0-2 Preston North End
Wanderers have little choice but to throw caution to the wind on Saturday, something which does not necessarily suit the players at Ainsworth's disposal. With no pressure on Preston, we are backing the visitors to record a relatively comfortable win at Adams Park.
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