Leicester Tigers hooker Tom Youngs will make his debut for England this weekend when they take on Fiji in their opening Autumn International at Twickenham.
The 25-year-old will come into the fray in Saturday, while wing Charlie Sharples has been named as Chris Ashton's replacement due to the Saracens player's suspension.
Ugo Monye has been included in the starting lineup on the left in place of the injured Ben Foden, while Brad Barritt has come in to take the place of Jonathan Joseph in the centres.
Meanwhile, Harlequins flanker Chris Robshaw has returned to the captain's role for the clash following his absence from the 14-14 draw with South Africa in June.
England team to play Fiji: A Goode; C Sharples, M Tuilagi, B Barritt, U Monye; T Flood, D Care; J Marler, T Youngs, D Cole, T Palmer, G Parling, T Johnson, C Robshaw (c), T Waldrom.
Replacements: D Paice, D Wilson, M Vunipola, J Launchbury, T Wood, B Youngs, O Farrell, M Brown.