Exeter Chiefs coach Rob Baxter has made just one change to the side which lost 9-6 to Leinster last weekend.
Australian international second-row Dean Mumm starts in place of James Hanks, who is demoted to the bench.
Clermont Auvergne once again name a star-studded lineup.
Suspended Nathan Hines is replaced by French international Julien Pierre in the side's only change.
Exeter: Arscott, Whitten, Dollman, Shoemark, Jess, Steenson, Thomas, Sturgess, Alcott, Rimmer, Hayes, Mumm, Johnson, Scaysbrook, Baxter
Clermont Auvergne: Byrne, Sivivatu, Rougerie, Fofana, Nalaga, James, Parra, Domingo, Kayser, Zirakashvili, Cudmore, Pierre, Vosloo, Bonnaire, Chouly