Aviva Premiership champions Saracens have announced that they will stage their Heineken Cup pool stage match against Biarritz in Cape Town.
European Rugby Cup and the International Rugby Board have approved an application from Sarries to host the game in South Africa's second biggest city on January 14, 2012.
"The world is becoming increasingly smaller and well connected, and, as a club, we are committed to thinking big and creating major events that people want to watch," said Sarries chairman Nigel Wray.
"We look forward to proceeding with these exciting plans, expanding the footprint and commercial value of European rugby."
It will be the first time a fixture in the tournament has been played outside of Europe.