The Aviva Premiership's top two sides meet at the Allianz Park on Sunday as leaders Saracens take on defending champions Harlequins.
Sarries have been in dominant form in recent weeks, winning seven out of their last eight league matches.
Quins come into the contest on the back of their LV= Cup victory over Sale Sharks, but their league form has been patchy with two losses out of four.
Both sides welcome a number of players back for the game following the conclusion of the Six Nations.
Sarries have named Alex Goode, Chris Ashton, Brad Barritt, Owen Farrell and Mako Vunipola in their starting lineup, while Kelly Brown is also included.
Meanwhile, the visitors will start with Mike Brown, Danny Care, Joe Marler and Chris Robshaw.
Recent form
Saracens: WLWWWL
Quins: LWWLWW
Lineups
Saracens: Goode, Ashton, Tomkins, Barritt, Strettle, Farrell, Wigglesworth, Joubert, raser, Brown, Hargreaves, Borthwick, Stevens, Brits, Vunipola
Replacements: Smit, Gill, Du Plessis, Kruis, Wray, De Kock, Hodgson, Wyles
Quins: Brown, Monye, Hopper, Turner-Hall, Smith, Evans, Care, Easter, Robshaw, Guest, Robson, Matthews, Johnston, Gray, Marler
Replacements: Buchanan, Lambert, Collier, Fa'asavalu, Wallace, Dickson, Botica, Lowe
Sports Mole says: Quins to edge out Sarries