Scotland centre Sean Lamont will miss the rest of the Six Nations after suffering a knee injury.
The 32-year-old picked up the problem while playing for Glasgow Warriors against Zebre on Friday.
Lamont has been replaced in Scotland's squad to face England this weekend by Sean Maitland, who missed the team's first three games due to a shoulder injury.
The Scots have lost all three of their matches so far in this year's Six Nations.