The coach has said in the run-up to this match that he has been pleased with his players' response in training following the 21-16 defeat at the Millennium Stadium last Friday.
Having come into the tournament with a healthy squad, Wales had been expected to recover from a mediocre winter, where they won just two of their four autumn matches, but they will need to win this weekend to remain in contention.
Meanwhile, the hosts have also made two changes as they look to put their defeat to France behind them in their first home match of this year's tournament.
The Scottish side earned praise for their performance in their 15-8 loss at Stade de France last Saturday, but were unable to hold off a late push from the hosts.
Euan Murray will not be available, as he does not play on Sundays for religious reasons, while wing Tommy Seymour is out with a hip injury, so Geoff Cross comes in at prop, while Sean Lamont earns a recall in place of Seymour.
Lamont's inclusion means that seven members of Glasgow Warriors' squad will be starting the match for the home side in Edinburgh.
Dougie Fife came on for Seymour when he sustained the injury last week, scoring Scotland's only try of the match, but he does not feature in Vern Cotter's matchday squad for the second fixture of the competition.
The hosts showed promise in the autumn with wins over Tonga and Argentina and a narrow defeat to world champions New Zealand, so they will be confident of continuing their strong home form.
However, Scotland have not beaten Wales in the Six Nations since 2007, and will be keen to make amends for last year's 51-3 humbling in Cardiff.
Recent form: WLWLWL
Starting lineup: Stuart Hogg, Sean Lamont, Mark Bennett, Alex Dunbar, Tim Visser, Finn Russell, Greig Laidlaw, Alasdair Dickinson, Ross Ford, Geoff Cross, Richie Gray, Jonny Gray, Rob Harley, Blair Cowan, Johnnie Beattie
Recent form: LLWLWL
Starting lineup: Leigh Halfpenny, Alex Cuthbert, Jonathan Davies, Liam Williams, Dan Biggar, Rhys Webb, Gethin Jenkins, Richard Hibbard, Aaron Jarvis, Jake Ball, Alun-Wyn Jones, Dan Lydiate, Sam Warburton, Taulupe Faletau
Sports Mole says 17-14