The Rossoneri were beaten by Fiorentina in Sinisa Mihajlovic's first league game as manager, while the Azzurri surrendered the lead in an eventual defeat against Chievo.
There is a huge amount of pressure on Milan to perform this season, after missing out on European qualification for the past two Serie A campaigns and getting nowhere near their title rivals.
The Rossoneri have invested heavily in their playing squad this summer, with the likes of Carlos Bacca and Luiz Adriano joining, while Mihajlovic has taken over from the much-maligned Filippo Inzaghi.
Heading into their opening match of the season against Fiorentina last Sunday, there were many suggesting that the club were capable of pushing for a Champions League spot, and possibly even challenging for the title.
However, that early optimism was soon crushed, as they slipped to a 2-0 defeat away to the Viola. They played the majority of the match with 10 men after Rodrigo Ely's first-half red card, although their opponents were in control before the sending-off.
The 25-year-old may not have been the most popular choice among the fans after his exit from the club last summer, but his record of 30 goals in 54 games during his first spell in Milan cannot be argued against.
Recent form: L
Despite last season's unexpected success in the top flight, many are predicting Empoli to struggle this time around, as they cope with a number of changes to their playing squad and backroom staff.
Marco Giampaolo was soon hired and given the task of keeping the club up, but his first match ended in disappointment as Empoli crashed out in the third round of the Coppa Italia to Serie B outfit Vicenza.
They looked to get over that upset last weekend, as they began their Serie A campaign with a home clash against Chievo, whom they had beaten 3-0 when the teams last met in February.
They have now lost five of their last six games in Serie A, and a return to form before the international break would be a welcome boost, especially with a clash against Sarri's Napoli to come when domestic business resumes.
Recent form: L
Balotelli is expected to be in the Milan squad after joining from Liverpool, but he is likely to start the match on the bench.
The Rossoneri will have to make do without the suspended Ely, so Cristian Zapata should replace him in the centre of the defence.
Giampaolo could make changes to his side following last weekend's defeat, but Massimo Maccarone should keep his place in the attack.
Manuel Pucciarelli and Saponara will be expected to provide him with support as they make up a five-man midfield.
AC Milan possible starting lineup:
Lopez, De Sciglio, Zapata, Romagnoli, Antonelli, De Jong, Bertolacci, Bonaventura, Honda, Adriano, Bacca
Empoli possible starting lineup:
Skorupski, Zambelli, Martinelli, Barba, Rui, Zielinski, Maeillo, Croce, Saponara, Pucciarelli Maccarone
Head To Head
Both of the league meetings between the clubs last season ended in draws, with the home side having a player sent off on each occasion.
The most recent of those games came at San Siro in February, where a second-half goal from Maccarone helped Empoli to salvage a 1-1 draw.
Milan have enjoyed a good record over the Azzurri in recent years and they have lost just two of the past 16 meetings between the clubs.
We say: AC Milan 1-0 Empoli
Milan will be hoping to put their disappointing start to the season behind them with an impressive showing in front of their home supporters. Their new players will take time to settle and it could be a while before they are at their best. It is a match that is expected to be tight, and Empoli could prove hard to break down, but we expect Milan to have just enough to pick up their first win of the campaign.