The Gunners crashed out at the first knockout stage last time out but are among the favourites to go all the way this time, though this could be a tricky opening test for them.
This is now Arsenal's fourth attempt at trying to win the Europa League, having previously reached the semi-finals and finished runners-up in 2018 and 2019 respectively.
The Gunners will be taking the competition seriously, too, although as ever the early rounds can often be a distraction from the bigger target - a top-four finish in the league.
Arsenal have made a good start to their season, winning three and losing two of their opening five league games, albeit with two of those defeats coming in their last three games.
That includes a slender 1-0 loss to Manchester City last time out, leaving Arteta's men fifth in the table with nine points from a possible 15.
With an EFL Cup quarter-final place already in the bag, focus now switches to the continent for the first time this season.
As well as facing Rapid Vienna home and away, Arsenal will also take on Norwegian and Irish champions Molde and Dundalk over the next two months.
Rapid boast plenty of experience in UEFA's secondary competition, with this their eighth campaign, reaching the knockout stages on two occasions previously - 2015-16 and 2018-19.
The Green-Whites are also in the early stages of their campaign and enter this game on the back of three straight wins, most recently thrashing Wiener Neustadt 5-1 in the cup, though they did face the disappointment of losing to Gent in Champions League qualifying.
After finishing second in the Austrian Bundesliga last season, the aim for Dietmar Kuhbauer this time around will be to finish above Red Bull Salzburg at the top of the pile.
This will be Rapid's first meeting with Arsenal, although the Austrian side did beat Aston Villa 3-2 in a Europa League qualifying match nine years ago in their most recent meeting with an English side.
Arsenal's last Austrian opponents were Austria Wien in the 1991-92 European Cup, meanwhile, winning that one 6-1 at home before losing 1-0 away.
Rapid Vienna form (all competitions): WLDWWW
Arsenal form (all competitions): WWLWWL
Summer signing Thomas Partey made his debut from the bench against Man City and is in contention to make his full debut here.
Bukayo Saka, who was directly involved in more goals in the Europa League last season than any other Arsenal player, is expected to be given a breather.
As for the home side, an unnamed player has tested positive for coronavirus in the build-up to the game and will therefore miss this match.
However, he was not in close contact with any of his teammates so Kuhbauer still has pretty much a full-strength squad to choose from.
Taxiarchis Fountas has four goals in four league appearances this season and is one to watch for Rapid.
Rapid Vienna possible starting lineup:
Strebinger; Stojkovic, Hofmann, Barac; Arase, Grahovac, Ljubicic, Ullmann; Murg, Kara, Fountas
Arsenal possible starting lineup:
Runarsson; Luiz, Gabriel, Kolasinac; Cedric, Elneny, Partey, Maitland-Niles; Willock, Nketiah, Nelson
We say: Rapid Vienna 1-2 Arsenal
Rapid Vienna have won four home games in a row in all competitions, whereas Arsenal are winless inside 90 minutes in their last three away games, losing two of those.
However, the Gunners were unbeaten in their four away matches in the Europa League last term and, even accounting for some rotation, we can see them prevailing at the Allianz Stadion.