Meanwhile, Sampdoria make the trip to the Gewiss Stadium sitting seven points clear of the relegation zone after recording back-to-back victories.
Given the points gap between third and fifth spot, fourth-placed Atalanta have effectively had the freedom to play attacking football for each match in its entirety for a number of months.
On the back of 10 successive wins in all competitions, Gian Piero Gasperini is unlikely to change his approach any time soon, but their run of form has put the club in closer proximity to second spot.
With Lazio and Inter Milan both losing at the weekend, Atalanta are now just five points adrift of their most realistic target, a position which they have never achieved in their history.
Although a trip to Juventus is due at the end of the week, there is no fear within this squad, who have recently added clean sheets to go with their relentless return in the final third.
Atalanta are 17 goals short of reaching treble figures, which would represent an astonishing achievement for a club who are not in contention for the league title.
Nevertheless, if Gasperini can ensure that everything continues to click in defence, they could emerge as Juventus' closest challengers over the next 12 months.
From Sampdoria's perspective, they will be relieved that they can travel to the Gewiss Stadium having created some space between themselves and the bottom three.
While two wins against any opposition would have been welcomed, they have been recorded against Lecce and SPAL, two of the sides occupying spots in the relegation zone.
Claudio Ranieri also required those results to boost his own standing in the dugout after previously overseeing just six victories from 22 games in charge, suffering 11 defeats.
The veteran boss and I Blucerchiati still have work to do in order to remain in the top flight, but this game arguably comes at an ideal time ahead of more winnable games over the next two weeks.
Atalanta BC Serie A form: WWWWWW
Sampdoria Serie A form: WLLLWW
Having witnessed his side run out 3-0 winners over SPAL, Ranieri could opt to select the same Sampdoria XI.
However, Gasperini is expected to make a number of alterations after resting several players for the game at Cagliari.
Atalanta BC possible starting lineup:
Gollini; Toloi, Caldara, Djimsiti; Hateboer, Roon, Pasalic, Gosens; Gomez; Zapata, Malinovskiy
Sampdoria possible starting lineup:
Audero; Bereszynski; Yoshida, Colley, Murru; Depaoli, Vieira, Ekdal, Linetty; Gabbiadini, Bonazzoli
We say: Atalanta BC 4-1 Sampdoria
Despite Sampdoria's recent revival, there is every chance that they will not be any match for this relentless Atalanta side. Although the home team may find themselves under slightly more pressure, it should not hinder their efforts on Wednesday evening.