The Spanish champions will enter this weekend's clash off the back of a 2-1 home defeat to Osasuna, while Alaves recorded an impressive 2-1 victory away to Real Betis in their last match.
Alaves appear set for their lowest finish in La Liga since earning promotion back to the top flight at the end of the 2015-16 campaign, but the fact that they have not been relegated during a tough season is a huge positive.
Under the management of Juan Muniz until the end of the campaign, the Basque club have lost 18 of their 37 league matches this season to sit down in 15th position in the table.
El Glorioso cannot be relegated, though, as they sit four points clear of 18th-placed Leganes, with their survival guaranteed courtesy of an impressive 2-1 victory at Real Betis on Thursday night.
The win in Seville was actually their first success in Spain's top flight since June 18, while they have lost each of their last six league games against Barca, including a 4-1 defeat at Camp Nou back in December.
Barca, meanwhile, as mentioned, will enter this match off the back of a shock 2-1 home defeat to Osasuna on Thursday night.
Relinquishing control of the La Liga title will have seriously hurt the club, but they still have the Champions League to play for this season and will face Napoli in the second leg of their last-16 clash on August 8, with the tie delicately poised courtesy of a 1-1 draw in Italy back in February.
Barca have actually dropped points in 10 of their 18 away league matches this season, while they could finish the campaign as many as 10 points behind the champions, which would be a huge disappointment.
Alaves La Liga form: LLLLDW
Barcelona La Liga form: DDWWWL
Alaves will be without the services of Rodrigo Ely due to the red card that the central defender picked up against Betis last time out, while Ruben Duarte and Fernando Pacheco are both definitely out through injury.
Araujo, Ansu Fati and Riqui Puig have actually been prevented from turning out for Barcelona B in their Segunda Division playoff against Real Valladolid's B team this weekend as they are needed in the first team.
Alaves possible starting lineup:
Jimenez; Aguirregabiria, Laguardia, Magallan, Marin; Mendez, Pina, Camarasa, Vidal; Joselu, Perez
Barcelona possible starting lineup:
Ter Stegen; Semedo, Araujo, Lenglet, Alba; Puig, Busquets, Roberto; Fati, Suarez, Messi
We say: Alaves 0-2 Barcelona
This match does not have anything significant riding on it, but there is no question that Barca will be determined to return to winning ways following the disappointment of the Osasuna result. Alaves are capable of causing Quique Setien's side problems, but we are fully expecting an away victory here.