Key Bayer Leverkusen striker Stefan Kiessling retains his place up front against Eintracht Braunschweig after his side finally got back to winning ways in midweek.
Andres Guardado starts for the hosts, with Lars Bender and Gonzalo Castro joining him in midfield for the fourth-placed side.
The away team continue with Havard Nielsen and Dominick Kumbela up front after both scored in their 3-1 win over Mainz 05 on Tuesday night.
Leverkusen: Leno; Donati, Toprak, Spahic, Boenisch; Bender, Can, Guardado; Castro, Kiessling, Son
Braunschweig: Davari; Kessel, Dogan, Correia, Reichel; Elabdellaoui, Vrancic, Boland, Hochscheidt; Nielsen, Kumbela