South Korean forward Son Heung-Min has been picked by Bayer Leverkusen boss Sami Hypia to make his home debut against Freiburg this afternoon.
Son will line up alongside Stefan Kiessling and Sidney Sam in a three-man attack for the hosts, with Ruben Castro providing support from midfield.
Giulio Donati has beaten competition from fellow summer signing Roberto Hilbert to make his debut at right-back, with Emir Spahic also making his Bundesliga bow in central defence.
Freiburg give Arsenal loanee Francis Coquelin a first start in midfield, while summer signings Mike Hanke and Admir Mehmedi also get the nod in attack.
Bayer: Leno, Donati, Spahic, Toprak, Boenisch, Reinartz, Bender, Castro, Sam, Kiessling, Son
Freiburg: Baumann, Sorg, Diagne, Ginter, Schmid, Fernandes, Schuster, Coquelin, Zuck, Hanke, Mehmed