After prevailing in their most recent fixtures, the teams sit 10th and 11th place respectively with just 10 matches remaining.
At the beginning of last week, Calgiari would have feared being dragged into a relegation battle if they were unable to end a winless streak which had been extended to 12 matches.
However, two victories in quick succession against SPAL and Torino have effectively ensured that focus can be switched to trying to end the campaign in the top seven.
Although they remain outsiders to achieve that target, Cagliari's resurgence has come as a welcome relief to Walter Zenga, who had to wait over three months to take charge of his first game.
After also showing promise in a narrow defeat at Hellas Verona, Zenga will have confidence that his players can only improve over the coming weeks at a time when they have been provided with a generally favourable schedule.
Giovanni Simeone has been the star of the show since the former Italy goalkeeper's arrival, netting in three successive games to take his tally to the season to nine strikes.
Like the visitors, Bologna returned to winning ways at the weekend after holding on to see off Sampdoria by a 2-1 scoreline.
The result ended a four-game streak without success, although their two most recent fixtures had been showdowns against Lazio and Juventus respectively.
I Rossoblu, now 12 points above the bottom three, can focus their attention on the teams above them as they look to at least equal their 10th position from last season.
However, that will only be achieved if Sinisa Mihajlovic's side can end their wait for a goal before the 70th minute, a run which has now been extended to five matches.
Bologna Serie A form: WLDLLW
Cagliari Serie A form: LLLLWW
Mihajlovic will almost certainly hand a recall to Musa Barrow, who impressed after his introduction from the substitutes' bench against Sampdoria.
Jerdy Schouten is in line to feature from the start after also making an impact as a replacement.
Zenga is unlikely to make any unnecessary changes to his Cagliari side after such a drastic improvement in form.
Despite being back in contention after a ban, midfielder Luca Cigarini is unlikely to return to the first XI at this time.
Bologna possible starting lineup:
Skorupski; Tomiyasu, Danilo, Bani, Dijks; Schouten, Medel, Soriano; Orsolini, Palacio, Barrow
Cagliari possible starting lineup:
Cragno; Walukiewicz, Ceppitelli, Carboni; Mattiello, Nandez, Rog, Lykogiannis; Nainggolan; Simeone, Pedro
We say: Bologna 2-2 Cagliari
At a time when both sides will be on a high, there will also be an acknowledgement that they have the freedom to push for all three points without being concerned about a relegation battle. However, this could lead to the teams cancelling each other out in an entertaining tussle.