Borussia Dortmund coach Jurgen Klopp has brought in Pierre-Emerick Aubameyang to his starting XI, with Henrikh Mkhitaryan going the other way to the bench.
The move sees Marco Reus move into the central role of the attacking three, while Marian Sarr keeps his place at centre-back, this time partnering Manuel Friedrich.
For the hosts, Sven Schipplock retains his place in attack, with both Kevin Volland and Roberto Firmino in support from midfield.
Hoffenheim: Grahl; Beck, Sule, Vestergaard, Toljan; Rudy, Polanski; Volland, Firmino, Herdling; Schipplock
Dortmund: Langerak; Piszczek, Friedrich, Sarr, Durm; Sahin, Kehl; Blaszczykowski, Reus, Aubameyang; Lewandowski
