The Blues are currently top of the table with 13 points, while Man City sit down in fifth position on 10 points, and here Sports Mole rounds up the team news for the two sides ahead of the mouthwatering contest.
Out: Christian Pulisic (ankle), Mason Mount (knock)
Doubtful: Edouard Mendy (knock)
Sports Mole's predicted XI: Mendy; Christensen, T Silva, Rudiger; Azpilicueta, Kante, Jorginho, Alonso; Havertz, Lukaku, Werner
Out: Benjamin Mendy (suspension)
Sports Mole's predicted XI: Ederson; Walker, Dias, Ake, Cancelo; De Bruyne, Fernandinho, Gundogan; Jesus, Torres, Grealish