This will be the 206th top-flight meeting between the two clubs, extending its record as the most played fixture in English football league history.
Aston Villa were unable to follow up their impressive victory at Goodison Park with another three points, as they were beaten 3-1 at home to Manchester United last weekend.
Bertrand Traore's emphatic finish midway through the first half helped the Villains take a narrow lead into the break, however second-half strikes from Bruno Fernandes, Mason Greenwood and Edinson Cavani ensured that the Red Devils came from behind to win once again, maintaining their unbeaten record away from home.
Ollie Watkins was shown a second yellow card late in the game for simulation, a decision manager Dean Smith was left "confused" by as he felt that VAR should have intervened to overturn the on-field referee's judgement.
Villa have recently seen their hopes of a European spot fade away but it has still been a successful campaign, considering they were fighting against relegation this time last year.
Smith's side head into Thursday's encounter with Everton having lost five of their last six games against teams currently above them in the table, but having beaten the Toffees just 12 days ago, they will fancy their chances of securing another win and finishing the season in the top half of the Premier League.
In fact, a victory for Villa in midweek would be the second shortest gap between one side beating another in Premier League history, after Bolton Wanderers lost twice to Arsenal in the space of three days back in January 2010.
Villa – who have won more Premier League games (20) and scored more league goals (73) against Everton than they have against any other side in the division – are looking to complete the league double over the Toffees for the first time since the 2000-01 campaign, which would help them move above Leeds United into 10th place.
Meanwhile, Everton are sure to finish inside the top half this campaign, improving on their disappointing 12th-place finish last season, and although they had ambitions of sneaking into the top four, an inconsistent home record appears to have put an end to those dreams.
Their defeat against Villa at the beginning of this month was their eighth at Goodison Park this term, double the number they lost in the whole of last season.
In stark contrast, Everton's away form has been fantastic, winning 11 and drawing three of their 17 games on the road; only Manchester City and Manchester United have claimed more points on their travels this campaign.
Their most recent away success was a narrow 1-0 victory at fellow European hopefuls West Ham United, who currently boast the second-best home record in the division.
Dominic Calvert-Lewin scored his 16th Premier League goal of the season to secure all three points for the Toffees, and the England international is now just five strikes behind compatriot Harry Kane in the race for the Golden Boot.
Everton travel to Villa Park on Thursday having won three of their last five away league matches against Aston Villa, however they did lose this fixture 2-0 last season.
Interestingly, manager Carlo Ancelotti has only won one of his six Premier League games against the Villains and against no other team does he have a lower win ratio (17%) in the division.
However, the Italian will not be fazed by such a statistic and he will be keen for his side to continue their impressive run of form away from home with a victory in midweek, to move them level on points with West Ham in fifth, one point clear of rivals Liverpool who play a few hours later against Man United.
Aston Villa captain Jack Grealish – who has missed the last 12 matches with a shin injury – has been training this week and there is a chance that he could be handed some minutes off the bench on Thursday, to boost his match fitness.
The absence of Watkins could see Brazilian striker Wesley start his first game for Villa since New Year's day 2020, after recovering from a cruciate knee ligament injury.
He could be joined in attack by Traore and Anwar El Ghazi – who scored the winning goal at Goodison Park earlier this month – while Ross Barkley is set to play against his boyhood club in an advanced midfield role.
As for Everton, James Rodriguez remains out with a calf injury that he picked up in the warm-up against Villa earlier this month.
Ancelotti decided to use a 3-5-2 formation against the Hammers and the Italian may choose to stick with this setup on Thursday, as opposed to the 4-2-3-1 lineup that he started with in the reverse fixture.
Mason Holgate could be recalled to the side at the expense of Yerry Mina to play alongside Michael Keane and Ben Godfrey in the heart of the defence, while Seamus Coleman and Lucas Digne are set to operate in wing-back roles.
Aston Villa possible starting lineup:
Martinez; Cash, Konsa, Mings, Targett; Nakamba, McGinn; Traore, Barkley, El Ghazi; Wesley
Everton possible starting lineup:
Pickford; Holgate, Keane, Godfrey; Coleman, Gomes, Allan, Sigurdsson, Digne; Richarlison, Calvert-Lewin
We say: Aston Villa 0-1 Everton
Aston Villa already know what it takes to defeat Everton, after beating them earlier this month, and they will fancy their chances of securing another victory on home soil.
However, the Toffees have been considerably stronger on the road this campaign and, with a win on Thursday evening needed if they are to secure a European spot, Ancelotti's men could prove tough to beat.
The hosts will also be without top scorer Ollie Watkins and so their threat in the final third may not be as testing for the visitors. With that in mind, we feel that Everton can continue their impressive away record with a narrow win at Villa Park.
Watch the Sports Mole Football Shorts prediction for this game below:
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