Juventus have the opportunity to grab their fifth consecutive Serie A victory on Friday if they beat Fiorentina on away turf.
Massimiliano Allegri's side maintained their three-point lead at the top of the league table with a 2-1 triumph over Torino at the weekend.
The Old Lady have just one blemish on their 13-match record in the top flight of Italian football, and they managed to clinch a slender 1-0 win over Fiorentina in this fixture last season.
Roma are the closest challengers to Juve at this point in the season, but Allegri's side have the opportunity to strengthen their position at the top with a six-point gap before their rivals face Sassuolo on Saturday.
Despite Fiorentina having a home advantage on Friday, Juventus have conceded just twice on their travels in seven Serie A contests this season.
For Vincenzo Montella's side, they currently reside eighth in the league standings after grabbing two consecutive victories following an inconsistent period.
Fiorentina, who are unbeaten in the Europa League, are just four points behind third-placed Napoli, but the team have conceded five goals in their last four games.
Despite suffering a 1-0 defeat to Napoli in their last home fixture, the team are expected to head into Friday's encounter with confidence after storming to a 4-0 win over Cagliari.
Plus, Juventus may have one eye on midweek's Champions League encounter at home to Spanish side Atletico Madrid.
Matias Fernandez and Mario Gomez are likely to lead the line for the hosts, while last weekend's goalscorers Arturo Vidal and Andrea Pirlo could start for Juventus.
Fiorentina:
Form in Serie A: DWLLWW
Form in all competitions: LDLWWW
Possible starting lineup: Neto; Alonso, Basanta, Gonzalo, Pizarro; Joaquin, Cuadrado, Savic, Valero; Fernandez, Gomez
Juventus:
Form in Serie A: WLWWWW
Form in all competitions: WWWWWW
Possible starting lineup: Storari; Lichtsteiner, Evra, Chiellini, BonuccI; Marchisio, Pirlo, Vidal, Pogba; Llorente, Tevez
Sports Mole says: 1-2