Fulham are third in the table, six points off the automatic promotion places, while neighbours Brentford are four points further back in fourth.
The three-month hiatus came at a bad time for Fulham, who had some momentum on their side in their pursuit of a top-two finish.
Scott Parker's side beat Swansea City and Preston North End in successive home games, sandwiched by away draws at Derby County and Bristol City, to close the gap on second place.
West Bromwich Albion picked up just one point from the last six on offer, though they are still six points better off than Fulham with only nine matches left to play.
Fulham know that they have to hit the ground running if they are to have a realistic shot of going up automatically, but they have two very tough games on their return to action.
After taking on Brentford this weekend, Parker's men then turn focus to league leaders Leeds United the following week, while a trip to West Brom is also on the horizon.
Brentford are not entirely out of the automatic promotion picture, with a favourable set of results this week potentially seeing them move to within seven points of second.
However, the immediate priority for the Bees is to hold off the chasing pack to secure a playoff spot, with just seven points separating them and Swansea down in 11th.
They remain winless in three away from home, though, and that could prove problematic as Fulham boast the best home form in the division - 12 wins and two draws in 19 matches.
Incredibly, however, the Cottagers have won just one of their last 18 home games against Brentford in all competitions - a 1-0 victory back in April 1990.
That is a run that they will need to put an end to on Saturday if they are to keep alive their hopes of an automatic return to the Premier League at the first attempt.
Fulham's Championship form: DLDWWD
Brentford's Championship form: DDDLDW
Fulham will be without loanee Terence Kongolo for the remainder of the season because of a foot injury sustained in February.
Central defender Alfie Mawson will also miss this first game back because of a knee problem, but Parker otherwise has a fully-fit squad to choose from.
The prolonged hiatus, meanwhile, has given Brentford an opportunity to get some key players back to full fitness.
Fulham possible starting lineup:
Rodak; Christie, Hector, Ream, Bryan; Arter, Cairney; Knockaert, Reid, Cavaleiro; Mitrovic
Brentford possible starting lineup:
Martin; Dalsgaard, Pinnock, Jansson, Henry; Mokotjo, Jensen, Dasilva; Mbeumo, Watkins, Benrahma
We say: Fulham 2-1 Brentford
Brentford have won just two of their last 10 away league outings, while Fulham have an unrivalled 38 home points this term in the second tier. Form may ultimately go out of the window this weekend, but we are still backing the hosts to grind out all three points against their West London rivals.