Mauro Icardi, the Nerazzurri's leading goalscorer this season with 16 goals, continues to spearhead the attack after opening the scoring last weekend.
Ex-Liverpool starlet Suso wins a starting berth after impressing off the bench last weekend, while Andrea Poli and Alex also come in as ninth-placed Milan look to move four points clear of their rivals in 10th.
Inter Milan XI: Handanovic; D'Ambrosio, Ranocchia, Vidic, Jesus; Gnoukouri, Medel, Kovacic; Hernanes; Palacio, Icardi
AC Milan XI: Diego Lopez; Abate, Alex, Mexes, Antonelli; Poli, De Jong, Van Ginkel; Suso, Menez, Bonaventura
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