In further positive news for the Juve head coach, both Leonardo Bonucci and Arthur came through their comebacks unscathed, both being introduced off the bench in the second half of Saturday's win over Lazio, while Juan Cuadrado was also fit enough to play 70 minutes.
However, Paulo Dybala remains out injured, while Rodrigo Bentancur tested positive for COVID-19 late last week and must self-isolate. Furthermore, versatile defender Danilo - who even featured in midfield last time out - is suspended on Tuesday.
The Bianconeri rearguard will necessarily be a mix-and-match affair then, so Pirlo is most likely to pair Bonucci with Merih Demiral in central defence, allowing Alex Sandro to switch back to the left flank.
Though substituted on Saturday, Aaron Ramsey has a strong chance of featuring in the starting XI again, given Bentancur's absence and Arthur's recent injury problems.
Juventus possible starting lineup:
Szczesny; Cuadrado, Bonucci, Demiral, Sandro; Chiesa, Rabiot, McKennie, Ramsey; Morata, Ronaldo