Ahead of the trip to Turin to meet Italian champions Juventus, Porto have concerns over the availability of key men Pepe and Jesus Corona, who both returned from the weekend win over Gil Vicente having suffered injuries.
Former Real Madrid centre-back and multiple Champions League winner Pepe suffered a calf strain, while 'Tecatito' was hurt in an aerial collision.
The Dragons' Chancel Mbemba is expected to be unavailable again, while Ivan Marcano may also not be fit enough to feature, causing a potential selection problem in central defence if Pepe cannot play.
Most probably, Diogo Leite will step in for Mbemba, with Malang Sarr also an option at the heart of the back four.
Otherwise, there are no further injury issues, so manager Sergio Conceicao is expected to have a nearly full squad at his disposal.
Having posed Juventus a number of problems in the first leg - and both found the net - Moussa Marega and Mehdi Taremi are set to be paired in Porto's front two.
Porto possible starting lineup:
Marchesin; Manafa, Pepe, Leite, Zaidu; Oliveira, Uribe, Otavio, Corona; Taremi, Marega
> Click here to see how Juventus could line up for this contest
