Juventus have a 1-0 half-time lead over Napoli in tonight's Serie A clash at the Juventus Stadium thanks to a Roberto Pereyra goal.
With two thirds of an historic treble already completed, Juve coach Massimiliano Allegri made nine changes to his starting lineup for the match.
The visitors did most of the pressing during the opening stages as Dries Mertens was denied by Gianluigi Buffon, before David Lopez's header from the resulting corner was kept out by the veteran goalkeeper.
Napoli were made to pay for those early misses with 13 minutes played when Pereyra slotted in confidently after being played in by Kingsley Coman.
Despite going behind, Napoli responded positively as Lopez flashed a shot wide of goal moments after Mertens had curled an effort high and wide.
Rafael Benitez's side continued to put pressure on the champions, but a lack of composure in the final third proved to be their downfall.
At the other end of the pitch, Paul Pogba came close to doubling Juve's advantage when he blazed a drive inches over the crossbar.
Napoli had a chance to get level with five minutes left in the half, only for Faouzi Ghoulam to shoot off target when he had plenty of support alongside him in the Juventus half.