Leeds' long-awaited return to the top flight could not get off to a more difficult start as they take on last season's runaway champions Liverpool at Anfield - a place where the Reds have not lost a league game since April 2017 and where they dropped only two points last season.
Newly-promoted Fulham visit Elland Road in Leeds' first home game back in the Premier League, but four of their opening five outings come against teams that finished in the top half last season.
April looks particularly daunting with last season's top three of Manchester City, Liverpool and Manchester United all in succession, while they end the campaign at home to fellow new boys West Bromwich Albion.
SEPTEMBER
12: Liverpool (a)
19: Fulham (h)
26: Sheffield United (a)
OCTOBER
3: Manchester City (h)
17: Wolves (h)
24: Aston Villa (a)
31: Leicester City (h)
NOVEMBER
7: Crystal Palace (a)
21: Arsenal (h)
28: Everton (a)
DECEMBER
5: Chelsea (a)
12: West Ham (h)
15: Newcastle (h)
19: Manchester United (a)
26: Burnley (h)
28: West Brom (a)
JANUARY
2: Tottenham (a)
12: Southampton (h)
16: Brighton (h)
27: Newcastle (a)
30: Leicester (a)
FEBRUARY
2: Everton (h)
6: Crystal Palace (h)
13: Arsenal (a)
20: Wolves (a)
27: Aston Villa (h)
MARCH
6: West Ham (a)
13: Chelsea (h)
20: Fulham (a)
APRIL
3: Sheffield United (h)
10: Manchester City (a)
17: Liverpool (h)
24: Manchester United (h)
MAY
1: Brighton (a)
8: Tottenham (h)
11: Burnley (a)
15: Southampton (a)
23: West Brom (h)