The hosts enjoyed a 1-0 victory over Angers in their most recent outing, whereas Reims suffered yet another defeat as they lost to Nimes by the same scoreline.
After a truly underwhelming start to the campaign, Lyon are finally starting to play like a side with intentions of breaking back into the Champions League.
Rudi Garcia has now witnessed his team take the spoils in four of their last five games - which includes that impressive 4-1 trouncing of Monaco last month - although the manner of Lyon's last two victories have not been so dominant.
Les Gones scraped past an out-of-sorts Saint-Etienne outfit 2-1 before travelling to mid-table Angers a week later, with Tino Kadewere's goal - his third in two games - enough to see Lyon eke out another vital win.
Garcia's men now boast an eight-game unbeaten run in the French top flight and have moved up to third in the table after 11 matches, and unlike the two sides above them in Lille and Paris Saint-Germain, Lyon can focus entirely on the domestic campaign with no Champions League or Europa League to worry about.
Injuries and positive coronavirus tests are piling up for the European-competing teams amid an unforgiving fixture list, which should play right into Lyon's hands ahead of the festive period.
While Reims supporters would have been heartbroken at their European journey ending so soon, their league position would undoubtedly be much more precarious if they were having to juggle domestic and Europa League commitments.
David Guion's men have started to pick up some long-overdue points in Ligue 1 but are still teetering dangerously close to the bottom three, with Reims only one point clear of 18th-placed Lorient and three above Strasbourg in 19th.
Les Rouges et Blancs' fortunes appeared to be improving with seven points taken from a possible nine against Montpellier, Strasbourg and Lens, but Reims were brought crashing back down to Earth with a narrow home defeat to Nimes last Sunday.
Renaud Ripart continued his fine goalscoring form against Reims as his penalty proved to be the difference between the two sides, although Guion's men have fared better on the road and can stretch their unbeaten away record to four matches in the top flight this weekend.
Reims' recent record against Lyon is certainly a cause for optimism; Les Gones are winless against the strugglers since 2015, with Les Rouges et Blances winning two of their last four against Lyon in the top flight.
Lyon Ligue 1 form: DWWDWW
Reims Ligue 1 form: DLWWDL
However, fellow midfielder Houssem Aouar will reportedly play no part in this one after the 22-year-old refused to partake in fitness work after last week's win over Angers - a game in which he was an unused substitute.
Reims have an integral player of their own returning from a ban, with Wout Faes set to be welcomed back to the defence with open arms after missing out the loss to Nimes.
Ghislain Konan could return from injury in time to compete with Thibault De Smet for the left-back spot, but Xavier Chavalerin and Anastasios Donis are both expected to remain sidelined for a little while longer.
The league's second-highest scorer Boulaye Dia, who was recently given a seal of approval by Sadio Mane, will look to build on the eight strikes he has already notched up this term as he leads the line with Kaj Sierhuis.
Lyon possible starting lineup:
Lopes; Dubois, Marcelo, Denayer, Cornet; Mendes, Caqueret, Guimaraes; Toko Ekambi, Depay, Kadewere
Reims possible starting lineup:
Rajkovic; Foket, Faes, Abdelhamid, De Smet; Cafaro, Munetsi, Berisha, Mbuku; Sierhuis, Dia
We say: Lyon 2-1 Reims
The Lyon faithful would have been somewhat disappointed to see their side only register the one goal against Angers, but a win is a win and Les Gones should keep that momentum going this weekend. Reims have been looking stronger in recent weeks and boast a solid record on unfamiliar territory, but we think the quality of Garcia's men will shine through and Lyon should march to their third win in a row on Sunday.
Top betting tip
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