Feyenoord vs. Lazio (Wednesday, 5.45pm)
Feyenoord welcome Lazio to De Kuip on Wednesday in the Champions League in what is set to be a hard-fought encounter as both sides have very real ambitions of making it through to the knockout rounds.
Lazio have the slight edge after two matches, thanks to their late draw with Atletico Madrid, while both have already recorded wins over Celtic in Group E.
We say: Feyenoord 1-1 Lazio
In what is a very tight encounter on paper, fine margins are likely to be decisive in what could well be a straight shoot-out for second place in Group E.
Feyenoord will be heavily weakened if Gimenez misses out with injury though, as their top scorer was the difference between the sides in this clash last season.
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Barcelona vs. Shakhtar (Wednesday, 5.45pm)
Barcelona will play their final game before Saturday's Clasico when they welcome Shakhtar Donetsk to Estadi Olimpic Lluis Companys for Wednesday's Champions League clash.
After kicking off their European campaign with consecutive victories, the Catalan giants sit top of Group H, while Shakhtar are in third position with three points to their name.
We say: Barcelona 2-0 Shakhtar Donetsk
While there may be a tendency for the Barcelona squad to have one eye on Saturday's Clasico, Xavi will be reminding his side to remain fully focused on the task at hand.
The Catalan outfit have coped well with the move to Estadi Olimpic Lluis Companys this season, and we believe they will continue their outstanding home form by claiming all three points in Wednesday's Champions League fixture.
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> How Barcelona could line up against Shakhtar Donetsk
> Barcelona injury, suspension list vs Shakhtar Donetsk
Celtic vs. Atletico (Wednesday, 8.00pm)
Celtic welcome Diego Simeone's Atletico Madrid to Parkhead in the Champions League on Wednesday.
After losing their first two games in the group, the hosts are on the brink of elimination, while Atletico are flying high, especially domestically.
We say: Celtic 0-2 Atletico Madrid
Failure to win in the Italian capital on matchday one means Atletico are winless in their last five Champions League group stage away games, but their recent form suggests they can end that run here.
Celtic have lost both of their opening games, and despite good form domestically, this will likely be a difficult evening, and their 10-year wait for a home win in this competition may go on.
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PSG vs. AC Milan (Wednesday, 8.00pm)
Separated by one point in the Champions League's so-called 'Group of Death', Paris Saint-Germain and AC Milan meet at Parc des Princes on Wednesday evening.
Ahead of next month's reverse fixture in Italy's second city, the teams go head to head in the French capital, with PSG aiming to bounce back from a humbling loss last time out in Group F and Milan seeking their first win.
We say: Paris Saint-Germain 1-1 AC Milan
Aside from their implosion in the Derby della Madonnina, Milan know how to keep things tight when required and came close to posting a fourth straight clean sheet in all competitions last weekend. Therefore, even PSG's attacking stars may find it tough to score more than once, and a share of the spoils would perfectly set up next month's return.
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Newcastle vs. Dortmund (Wednesday, 8.00pm)
Having won six of their last eight games, most notably on a Champions League night to remember, Newcastle United face German giants Borussia Dortmund at St James' Park on Wednesday evening.
The first competitive meeting between two proudly-backed clubs comes with the hosts sitting on four points in Group F, following a spectacular defeat of Paris Saint-Germain; Dortmund, meanwhile, are still seeking their first win.
We say: Newcastle United 2-1 Borussia Dortmund
Defeat for Dortmund would be their 50th loss in the Champions League, and such a result would put them in real trouble regarding progress from Group F. However, Newcastle are currently in no mood to take their foot off the gas, and victory on home soil will give them a further fillip before next month's reverse fixture in Germany.
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RB Leipzig vs. Red Star (Wednesday, 8.00pm)
RB Leipzig will expect to return to winning ways in Group G when they host Red Star Belgrade in the Champions League on Wednesday.
The Serbian SuperLiga champions have lost one and drawn one of their opening two matches.
We say: RB Leipzig 3-1 Red Star Belgrade
Leipzig will know the importance of collecting all three points in this match, as it would likely put them in an incredibly strong position to progress from Group G.
Red Star will be no pushovers, though, having shown plenty of resolve in their first two matches. While we can see them threatening the hosts on occasions, Rose's side should have too much quality in the end.
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Young Boys vs. Man City (Wednesday, 8.00pm)
Champions League holders Manchester City will expect to make it three wins from three in Group G when they visit Young Boys on Wednesday.
The Swiss Super League champions have lost one and drawn one of their opening two matches.
We say: Young Boys 0-2 Manchester City
Despite Guardiola being likely to make some changes to his starting XI ahead of the Manchester derby on Sunday, we expect the visitors to have too much quality for their opponents.
Young Boys have dominated Swiss football in recent years, but it is clearly a huge step up in class for them to be taking on the holders, and they may struggle to lay a glove on Man City even with home advantage on their side.
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> How Man City could line up against Young Boys
> Man City injury, suspension list vs. Young Boys
Antwerp vs. Porto (Wednesday, 8.00pm)
Royal Antwerp will attempt to claim their first-ever points in the Champions League group stage when they welcome Porto to Bosuilstadion on Wednesday.
The Belgium side are currently languishing at the foot of Group H, while their Portuguese opponents are in second position with three points to their name after two matches.
We say: Royal Antwerp 0-2 Porto
Antwerp have shown some defensive vulnerabilities in their opening two group games, and we believe a shaky backline could be their downfall on Wednesday.
In contrast to their hosts, Porto are usually a hard team to break down, and we think their defensive resilience will lay the foundations for a crucial victory.
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