The Argentina striker remains sidelined with a knee injury and is facing a race against time to be fit for the resumption of the Champions League next month.
City manager Pep Guardiola otherwise has a full-strength squad to choose from, with no fresh concerns following Sunday's defeat at Southampton.
Newcastle head coach Steve Bruce is facing a selection headache ahead of the trip to the Etihad Stadium.
Frontmen Allan Saint-Maximin (fatigue), Miguel Almiron (thigh) and Andy Carroll (groin) are all doubts following their exertions against City in the FA Cup quarter-final and Bournemouth and West Ham in the league in the last 10 days and will be assessed.
Isaac Hayden limped out of Sunday's 2-2 draw with the Hammers with a hamstring strain, the same injury which prevented fellow midfielder Sean Longstaff from playing a part in the game, and both are likely to miss out.
Manchester City provisional squad: Ederson, Bravo, Walker, Cancelo, Stones, Otamendi, Laporte, Fernandinho, Garcia, Harwood-Bellis, Zinchenko, Mendy, Gundogan, Rodri, D Silva, De Bruyne, B Silva, Foden, Sterling, Mahrez, Doyle, Jesus.
Newcastle provisional squad: Dubravka, Darlow, Yedlin, Rose, Krafth, Lazaro, Manquillo, Lascelles, Fernandez, Schar, Bentaleb, Shelvey, M. Longstaff, Ritchie, Saint-Maximin, Allan, Almiron, Joelinton, Carroll, Gayle, Muto.