Despite losing three times in their last half-a-dozen league outings, City possess an eight-point advantage over third-placed Leicester City.
Although there is little riding on the game at the Etihad Stadium, Pep Guardiola will be eager for his side to produce a positive response after their surprise setback at Southampton on Sunday evening.
Here, Sports Mole predicts how City could line up for the visit of the Magpies.
Out: Sergio Aguero (knee)
Faced with a third fixture in the space of a week and having only used two substitutes at St Mary's, Guardiola is expected to make sweeping changes to his team on Wednesday evening.
Despite a goalless streak which has now lasted nine matches, Gabriel Jesus is in line to retain his spot in the middle of the attack.
Sergio Aguero, who sustained a knee injury at the end of last month, is not expected to return until August at the earliest.