Fresh from Saturday's 4-1 defeat at Watford in the Premier League, Manchester United will resume their Champions League campaign with a clash against Villarreal on Tuesday.
The loss at Vicarage Road made it five defeats from their last seven league matches, which has seen the Red Devils fall 12 points off the top of the Premier League table.
The Red Devils are currently top of their Champions League section, though, picking up seven points from four matches in Group F, which has left them on course for the knockout round of the competition.
Here, Sports Mole rounds up all of Man United's latest injury and suspension news ahead of their trip to Spain.
Status: Out
Type of injury: Coronavirus
Possible return date: Unknown
Mason Greenwood was ruled out of Saturday's clash with Watford after testing positive for coronavirus, and the attacker is currently undergoing a period of self-isolation.
Status: Out
Type of injury: Thigh
Possible return date: Unknown
Paul Pogba sustained a thigh injury during the recent international break, and it is unlikely that the French midfielder will be able to return until 2022.
Status: Out
Type of injury: Hamstring
Possible return date: December 5 (vs. Crystal Palace)
Raphael Varane remains on the sidelines with a hamstring injury, but the France international has a chance of recovering from the issue in time for the clash with Crystal Palace on December 5.
Status: Major doubt
Type of injury: Concussion
Possible return date: November 23 (vs. Villarreal)
Shaw needed to be withdrawn through concussion during the loss to Manchester City before the international break; he featured against Watford on Saturday but had to leave the field in the second half due to another suspected concussion, meaning that he is a major doubt for this match.
Status: Major doubt
Type of injury: Tendon
Possible return date: November 23 (vs. Villarreal)
Edinson Cavani missed out on Uruguay's recent fixtures due to a tendon injury, while he has not featured in Man United's last two matches against Man City and Watford, meaning that he remains a major doubt for this game.
MAN UNITED'S SUSPENSION LIST
Man United have no suspension concerns for the European fixture.