After a goalless first leg in Spain last month, the Red Devils were expected to take the game to their visitors to avoid the possible sucker-punch of an away goal.
The Moroccan striker bagged another four minutes later and although United pulled one back through Romelu Lukaku six minutes from time, it was too little, too late.
Relive how the action unfolded in Manchester with our minute-by-minute updates below.
Subs: Romero, Darmian, Lindelof, Mata, McTominay, Pogba, Martial
Subs: Ben Yedder, Geis, Soria, Pizarro, Pareja, Nolito, Lopes
At the other end Sevilla work it nicely to Sarrabia on the right wing, and his cross could easily have been turned past De Gea by either Muriel or Bailly as they duelled at the near post.