Eric Bailly, Paul Pogba and Marcus Rashford have all come into the Manchester United side for Tuesday's Champions League clash with Atalanta BC in Italy.
Red Devils manager Ole Gunnar Solskjaer has decided to stick with the 3-5-2 formation that proved to be a success in Saturday's Premier League clash against Tottenham Hotspur.
However, there are three changes to the starting side, with Bailly, Pogba and Rashford coming in for Victor Lindelof, Fred and Edinson Cavani.
Lindelof did not travel to Italy due to a knock, but Fred and Cavani are both on the bench for the 20-time English champions ahead of Saturday's derby with Manchester City.
Aaron Wan-Bissaka and Luke Shaw will again operate in the wing-back areas for Man United, while Bruno Fernandes will be looking to link with Rashford and Cristiano Ronaldo in the final third of the field.
A strong bench includes the likes of Jesse Lingard, Mason Greenwood, Anthony Martial and Jadon Sancho, with Solskjaer having plenty of options for change in Italy.
Full Manchester United XI: De Gea; Bailly, Varane, Maguire; Wan-Bissaka, Fernandes, McTominay, Pogba, Shaw; Ronaldo, Rashford body check tags ::
