Wolves vs. Liverpool (Saturday, 12.30pm)
Aiming to pick up where they left off before the international break, Liverpool take on Wolverhampton Wanderers in Saturday's early Premier League kickoff.
Jurgen Klopp's men swatted aside Aston Villa 3-0 in gameweek four, while their hosts were on the receiving end of a 3-2 beating at the hands of Crystal Palace.
We say: Wolverhampton Wanderers 0-2 Liverpool
Late arrivals back from South America and an ongoing selection crisis at the back could serve to derail Liverpool's aspirations of a fourth consecutive win, but the returning Gomez and Matip formed an effective barrier against Villa and should feel confident of doing the same against an inconsistent Wolves attack.
The likes of Diogo Jota and Cody Gakpo can also step up to the plate if Diaz and Nunez are spared, and O'Neil's side should not stop the Liverpool juggernaut this Saturday lunchtime.
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> How Liverpool could line up against Wolves
> Liverpool injury, suspension list vs. Wolves
Aston Villa vs. Crystal Palace (Saturday, 3.00pm)
Aston Villa will be looking to leapfrog Crystal Palace in the Premier League table when they welcome the Eagles to Villa Park on Saturday afternoon.
While the hosts have picked up six points from a possible 12 available so far this season, the visitors have accumulated seven points from their first four top-flight fixtures.
We say: Aston Villa 2-1 Crystal Palace
There has been little to separate Aston Villa and Crystal Palace in recent years, with the two teams picking up seven points each across the last five Premier League meetings, and another closely-fought contest could be in store on Saturday.
Palace have the potential to cause Villa problems in attack, but we believe that Villa, who boast an impressive home record, will outscore their opponents en route to claiming maximum points.
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Fulham vs. Luton (Saturday, 3.00pm)
Still without a home win in the 2023-24 Premier League season, Fulham seek to right those wrongs when they welcome newly-promoted Luton Town to Craven Cottage on Saturday.
Marco Silva's seething side fell to a 5-1 humbling at the hands of champions Manchester City two weekends ago, while the Hatters' losing streak continued with a 2-1 home beating at the hands of West Ham United.
We say: Fulham 3-1 Luton Town
Given their tendency to ship goals and an injury crisis in the middle of the park, Fulham may not come out of Saturday's battle unscathed, even if the tough-tackling Palhinha is reintroduced into the fray.
Luton's own rearguard record is only marginally better, though, and the international break should have done Silva's side the world of good, so we can only envisage the Cottagers rectifying their recent mistakes with a much-needed maximum.
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Man Utd vs. Brighton (Saturday, 3.00pm)
Seeking to climb into the top half of the Premier League table, Manchester United play host to Brighton & Hove Albion at Old Trafford on Saturday afternoon.
While the Red Devils are languishing in 11th place at this early stage of the campaign, the Seagulls are sitting in the top six and just three points behind leaders Manchester City.
We say: Manchester United 2-2 Brighton & Hove Albion
A closely-fought contest between an under-pressure Man United side and buoyant Brighton outfit is set to take place this weekend, and it is difficult to predict a favourite for this fascinating match-up.
Brighton have scored in each of their last 15 Premier League away games and will be confident of breaching Man United's backline, but we believe that the hosts will find a way to claim a share of the spoils.
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> How Man United could line up against Brighton
> Man United injury, suspension list vs. Brighton
> Marcus Rashford's record vs. Brighton & Hove Albion
Spurs vs. Sheff Utd (Saturday, 3.00pm)
On the back of a brilliant start to life under Ange Postecoglou, Tottenham Hotspur resume Premier League duties at home to Sheffield United on Saturday afternoon.
The Lilywhites demolished newly-promoted Burnley 5-2 just before the international break, while the Blades picked up their first point in a 2-2 draw at home to Everton.
We say: Tottenham Hotspur 3-0 Sheffield United
The international break undoubtedly came at a better time for Sheffield United than a Tottenham team with the wind in their sails, but we can only see Postecoglou's lively crop picking up where they left off.
A plethora of defensive injury concerns is the last thing the doctor ordered for the Blades before a journey to North London, where another multiple-goal triumph is surely on the cards for those in white.
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> How Tottenham could line up against Sheffield United
> Tottenham injury, suspension list vs. Sheffield United
West Ham vs. Man City (Saturday, 3.00pm)
Two unbeaten Premier League teams currently sitting inside the top four lock horns at the London Stadium on Saturday afternoon as West Ham United play host to reigning champions Manchester City.
While the Hammers are seeking to win a fourth successive league match for the first time in nearly two years, the Citizens are looking to preserve their 100% start in the top flight and maintain their position at the top of the table.
We say: West Ham United 1-3 Manchester City
An intriguing contest between two in-form teams brimming with confidence could be in store on Saturday, although West Ham understandably enter this match as underdogs against the reigning champions.
The Hammers have the potential to cause Man City problems in the final third, particularly from set-pieces and on the counter-attack, but the Citizens possess enough attacking quality of their own to outscore their opponents and claim a fifth straight league victory.
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> How Man City could line up against West Ham
> Man City injury, suspension list vs. West Ham
Newcastle vs. Brentford (Saturday, 5.30pm)
Aiming to snap their miserable losing run before commencing Champions League duties, Newcastle United welcome Brentford to St James' Park for Saturday's tantalising Premier League showdown.
Eddie Howe's men were outfought and outclassed in a 3-1 loss to Brighton & Hove Albion two weeks ago, while the Bees remain unbeaten thanks to a 2-2 draw versus Bournemouth.
We say: Newcastle United 2-1 Brentford
The Bees' recent affinity for draws might serve them well up north, where concerns over Tonali and Botman's respective fitness levels will do the demoralised Magpies no favours whatsoever.
However, with Brentford still showcasing a tendency to ship goals and Newcastle more than capable of turning their fortunes around at home - especially with the Champions League on the horizon - we expect Howe's team to return from the international break with a bang and secure a fourth successive win over their capital counterparts.
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