Millwall have made six changes to their starting XI following their Capital One Cup exit to Nottingham Forest midweek.
David Forde returns in goal while Alan Dunne and Danny Shittu come into the back four.
Scott McDonald continues as the lone striker, while Richard Chaplow takes over from Nadjim Abdou in midfield.
Brighton & Hove Albion have stuck with the same players that started during their 2-0 win over Burnley last Saturday.
Brighton: Kuszczak, Greer, Calderon, Ward, Upson, Crofts, Agustien, Lopez, Ulloa, Buckley, Ince
Millwall: Forde, Dunne, Beevers, Shittu, Lowry, Henry, Bailey, Woolford, Derry, Chaplow, McDonald