Napoli have Pepe Reina back in goal for the first time in 2014, while Jorginho gets his first start since moving from Hellas Verona in tonight's Coppa Italia quarter-final clash against Lazio.
Lorenzo Insigne, Marek Hamsik and Jose Callejon will line up behind centre-forward Gonzalo Higuain, meaning that Goran Pandev will be on the bench against his former club.
Pablo Armero, Valon Behrami, Giandomenico Mesto and Juan Camilo Zuniga are all unavailable for Partenopei manager Rafael Benitez.
Lazio will take to the San Paolo with a depleted team, as Miroslav Klose is suffering from flu, while Stefan Radu and Ederson are injured. Meanwhile, Stefano Mauri is banned.
Sergio Floccari did not make the trip to Naples, as he is ready to join Sassuolo.
The 20-year-old Colombian Brayan Perea and 18-year-old ex-Barcelona talent Keita Balde are the only available forwards.
Etrit Berisha is again in goal, as Federico Marchetti has not fully recovered from last week's stomach bug.
Napoli: Reina, Maggio, Fernandez, Albiol, Reveillere, Jorginho, Inler; Insigne, Hamsik, Callejon, Higuain
Lazio: Berisha, Ciani, Novaretti, Dias, Konko, Onazi, Ledesma, Lulic, Anderson, Keita, Perea
