Gonzalo Higuain will lead the line for Napoli in their opening Serie A match against Genoa this evening.
The striker bagged 24 goals for the club in all competitions last season and will receive support in the attack from Lorenzo Insigne, Marek Hamsik and Jose Callejon.
There is also a league debut for defender Kalidou Koulibaly, who arrived from Genk in the summer.
Meanwhile, Mauricio Pinilla makes his first start for the hosts after his summer move from Cagliari, with fellow new arrival Diego Perotti also in the side.
Genoa: Perin, De Maio, Burdisso, Marchese, Edenilson, Sturaro, Rincón, Antonelli, Falque, Pinilla, Perotti
Napoli: Rafael, Maggio, Albiol, Koulibaly, Zuniga, Inler, Jorginho, Insigne, Hamsik, Callejon, Higuain