Portugal are sweating over the fitness of Diogo Jota ahead of their World Cup 2022 Qualifying battle with Luxembourg in Group A on Tuesday.

The Liverpool attacker was nowhere to be seen in Saturday's friendly win over Qatar due to a muscular issue, and the quick turnaround in fixtures makes him a major doubt for this contest.

Raphael Guerreiro, Rafa Silva and Domingos Duarte have also been forced to withdraw due to injuries, while Francisco Trincao will play no part after a positive coronavirus test.

Diogo Costa earned his first cap for the national team in the weekend's 3-0 win but is set to make way for Rui Patricio here, with the Roma goalkeeper poised to win his 100th cap for the national team.

Joao Cancelo, Pepe and Ruben Dias should all earn recalls to the backline as Diogo Dalot, Jose Fonte and Danilo Pereira drop out, but Nuno Mendes's spot at left-back could be safe following Guerreiro's injury.

Fernando Santos also ought to make a full complement of changes in midfield, with Joao Moutinho, Joao Palhinha and Bruno Fernandes all well-rested and pushing for inclusion from the first whistle.

Cristiano Ronaldo started and scored against Qatar after Santos affirmed that the Manchester United man needed playing time, and the five-time Ballon d'Or winner could be joined by Bernardo Silva and AC Milan's Rafael Leao if Jota is not passed fit.

Portugal possible starting lineup: Patricio; Cancelo, Pepe, Dias, Mendes; Moutinho, Palhinha, Fernandes; B. Silva, Ronaldo, Leao