Real Madrid have confirmed that centre-back Pepe has been hampered by a foot complaint.
The injury forced the Portuguese international to miss the 6-0 victory over Espanyol at the weekend.
Los Blancos have not revealed the extent of the damage and have also provided no timescale as to the potential length of the 32-year-old's absence.
Pepe has made 17 appearances in all competitions for Madrid this season.
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| Team | P | W | D | L | F | A | GD | PTS | |
| 1 | Barcelona | 8 | 7 | 0 | 1 | 25 | 9 | 16 | 21 |
| 2 | Real Madrid | 7 | 5 | 2 | 0 | 16 | 5 | 11 | 17 |
| 3 | Atletico MadridAtletico | 7 | 4 | 3 | 0 | 11 | 3 | 8 | 15 |
| 4 | Athletic Bilbao | 8 | 4 | 2 | 2 | 12 | 8 | 4 | 14 |
| 5 | Mallorca | 8 | 4 | 2 | 2 | 8 | 6 | 2 | 14 |
| 6 | Villarreal | 7 | 4 | 2 | 1 | 14 | 14 | 0 | 14 |
| 7 | Osasuna | 8 | 4 | 2 | 2 | 12 | 13 | -1 | 14 |
| 8 | Rayo Vallecano | 8 | 2 | 4 | 2 | 9 | 8 | 1 | 10 |
| 9 | Celta Vigo | 8 | 3 | 1 | 4 | 15 | 15 | 0 | 10 |
| 10 | AlavesAlaves | 8 | 3 | 1 | 4 | 11 | 12 | -1 | 10 |
| 11 | Real BetisBetis | 7 | 2 | 3 | 2 | 7 | 7 | 0 | 9 |
| 12 | GironaGirona | 8 | 2 | 3 | 3 | 9 | 11 | -2 | 9 |
| 13 | Sevilla | 8 | 2 | 3 | 3 | 8 | 10 | -2 | 9 |
| 14 | Real Sociedad | 8 | 2 | 2 | 4 | 6 | 7 | -1 | 8 |
| 15 | Getafe | 8 | 1 | 4 | 3 | 5 | 6 | -1 | 7 |
| 16 | Espanyol | 7 | 2 | 1 | 4 | 7 | 11 | -4 | 7 |
| 17 | Leganes | 8 | 1 | 4 | 3 | 5 | 9 | -4 | 7 |
| 18 | Valencia | 8 | 1 | 2 | 5 | 5 | 13 | -8 | 5 |
| 19 | Real ValladolidValladolid | 8 | 1 | 2 | 5 | 4 | 17 | -13 | 5 |
| 20 | Las PalmasLas Palmas | 7 | 0 | 3 | 4 | 8 | 13 | -5 | 3 |
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