Celta Vigo vs. Real Betis (Saturday, 5.00pm)
The visitors are unbeaten in their last five meetings with Los Celestes, including a 2-1 victory against them on home soil in January.
We say: Celta Vigo 1-1 Real Betis
Both Celta and Real Betis head into the final game of the season in good form, with more riding on the match for the visitors, who know that a win will guarantee European football for next season. However, with little to separate the two teams, a score draw could be on the cards at Estadio de Balaidos.
Eibar vs. Barcelona (Saturday, 5.00pm)
Ronald Koeman's side cannot finish higher than third but could still drop into fourth on the final weekend of the campaign, while Eibar's relegation was confirmed when they lost 4-1 to Valencia on Sunday night.
We say: Eibar 0-2 Barcelona
Barca will be desperate to sign off with a win, and we are finding it very difficult to look past the visitors here. Eibar have found it difficult to compete in the top flight this term, and we are backing a routine two-goal success for Koeman's side, which would ensure that they finish in third position.
Huesca vs. Valencia (Saturday, 5.00pm)
For Huesca to retain their top-flight credentials, the task is straightforward enough: pick up the three points, maintain a better goal difference than Elche and hope their relegation rivals lose.
We say: Huesca 1-0 Valencia
Huesca come into this game on the back of a couple of good home wins and, with desperation, hope and the plight of survival on their side, we think Pacheta's men will give Valencia a run for their money and pick up the three points.
Osasuna vs. Real Sociedad (Saturday, 5.00pm)
Imanol Alguacil's La Real will hope to cement Europa League football next season with three points on Saturday, while Osasuna could still finish in the top half of the division with a win this weekend.
We say: Osasuna 0-2 Real Sociedad
La Real are in a hot vein of form and look very capable of getting the better of Osasuna this weekend. We are expecting goals from the man of the hour Isak.
Real Madrid vs. Villarreal (Saturday, 5.00pm)
Los Blancos are currently second in the table, two points behind leaders Atletico, while Villarreal sit seventh, one point behind fifth-placed Real Sociedad, meaning that both sides have plenty to play for in Madrid.
We say: Real Madrid 2-1 Villarreal
Villarreal are a team to be taken extremely seriously at this level of football, but the Yellow Submarine will have one eye on the Europa League final. We are expecting a tight match in the Spanish capital but expect Zidane's side to secure all three points, which could yet be enough to win the title.
Real Valladolid vs. Atletico (Saturday, 5.00pm)
Atletico Madrid will travel to relegation-threatened Real Valladolid on Saturday evening knowing that a victory would guarantee themselves the La Liga title.
Diego Simeone's side are top of the division ahead of the final round of fixtures, two points clear of second-placed Real Madrid, while Valladolid are 19th, two points from safety as they battle to stay in the division.
We say: Real Valladolid 0-1 Atletico Madrid
Atletico know that a win will be enough to win the title, and we are finding it difficult to look as the visitors. Valladolid are also in desperate need of the points, but we are expecting the home side to fall short, which would see them relegated back to the second tier of Spanish football.
Elche vs. Athletic Bilbao (Saturday, 5.00pm)
The mission for Fran Escriba's Elche is simple: pick up all three points against their Basque visitors and pray results are favourable elsewhere.
We say: Elche 1-2 Athletic Bilbao
While three points for Elche would certainly be a fairytale end to the campaign for the club, we think Athletic will prove to be too much for Escriba's men. Elche made a splash when they beat Cadiz last time out, and we are not sure they will be able to do the same against Athletic.