Real Madrid will be looking to record a home La Liga win over Atletico Madrid for the first time since 2012 when the capital rivals lock horns on Saturday afternoon.
Los Blancos have lost three and drawn three of their last six league meetings with Atletico at the Bernabeu, but Zinedine Zidane's side have won their last seven matches in all competitions during a strong run.
A win for the hosts this weekend would move them six points clear at the top of La Liga as second-placed Barcelona are not in action until Sunday night.
Here, Sports Mole looks at how Real Madrid could line up against their bitter rivals.
Out: Marco Asensio (knee), Eden Hazard (ankle)
Doubtful: Gareth Bale (ankle)
> Click here for Real Madrid's latest injury and suspension news ahead of this match
Real Madrid will again be without the services of long-term absentees Marco Asensio and Eden Hazard despite the fact that both players are making positive progress in their recoveries.
Gareth Bale could be involved following an ankle problem, although it seems unlikely that the Wales international will be thrown back into the starting XI for this match.
Dani Carvajal has served a one-match league suspension and should return, though, while the likes of Ferland Mendy, Luka Modric and Karim Benzema will start having been left out of Wednesday's Copa del Rey clash with Real Zaragoza.
Lucas Vazquez was on the scoresheet in the 4-0 win over Zaragoza and is pushing to start alongside Benzema and Rodrygo Goes in the final third of the field.
Federico Valverde could be the odd man out in midfield despite his impressive form this season, while Isco and Vinicius Junior are likely to be named on the bench this weekend.
>Click here to see how Atletico could line up for this fixture