Los Blancos are currently top of the pile with 52 points, three clear of the reigning champions Barcelona following five straight victories in Spain's top flight.
Zinedine Zidane's side have only actually lost once in the league this season, while they are unbeaten against 17th-placed Celta in La Liga at the Bernabeu since November 2006.
Here, Sports Mole looks at how the capital outfit could line up on home soil.
Marco Asensio will again miss out for Madrid as the Spaniard continues to recover from a knee problem, but Eden Hazard is in line to return to the squad having overcome an ankle injury.
The Belgium international has not turned out for Zidane's team since the end of November but has trained throughout the week and is expected to be on the bench for this match.
James Rodriguez also took part in full-contact training on Friday, although the clash with Celta is expected to come too soon for the Colombian, who has been struggling with a hip problem.