The Giallorossi arrive in the Albanian capital with all of their first-team squad fit and healthy, as Armenian midfielder Henrikh Mkhitaryan is back in the fold following a hamstring injury that has recently ruled him out.
Recently recovered from a muscular issue, Nicolo Zaniolo is expected to replace Eldor Shomurodov, as Jose Mourinho makes at least one change to the side which started Roma's final-day Serie A win over Torino.
Out for the best part of a year with two serious knee ligament injuries, Zaniolo has been prone to picking up niggles since, so young Felix Afena-Gyan is on standby as a potential wildcard selection by Mourinho.
Bryan Cristante will also be targeting Jordan Veretout's spot in midfield, and ex-Feyenoord wing-back Rick Karsdorp is likely to be brought back into the starting XI, but who drops out as a result remains undetermined.
Finally back from the long layoff which followed his injury at last summer's European Championships, Leonardo Spinazzola lined up on the left last time out - with Polish rookie Nicola Zalewski featuring on the opposite flank.
Up front, meanwhile, star striker Tammy Abraham leads the line, and is currently the competition's second-top scorer. Supporting from an advanced midfield role will be club captain Lorenzo Pellegrini, with fellow Italy international Stephan El Shaarawy offering an experienced attacking option from the bench.
Roma possible starting lineup: Patricio; Mancini, Smalling, Ibanez; Karsdorp, Cristante, Oliveira, Zalewski; Pellegrini, Zaniolo; Abraham