Lazio are now just six points adrift of table toppers Juventus with a game in hand, while Roma are a further seven points back in fourth.
Roma are enduring something of a disappointing campaign and, with just 20 rounds played, they are already out of the running for the Serie A title.
With two defeats from their last three matches, Roma have been vulnerable of late and have managed just five wins at home all season.
Injuries to key players have certainly played their role in recent weeks, with Roma having lost just twice in Serie A between August and December, but consecutive defeats on their return from the winter break have really damaged their hopes of securing Champions League football for next season.
A win would take them to within four points of Lazio, who sit third, but a defeat would leave them vulnerable to Atalanta and cut them further adrift from the pace setters.
Roma and Lazio drew in the reverse fixture in September, but the home side will face a very different Lazio side to the one that featured that day.
Simone Inzaghi's side are Serie A's form team and have won their past 11 league matches.
In total, they have scored 49 goals from just 19 league matches and Ciro Immobile has registered 23 goals from just 18 starts.
Having lost two of their opening five Serie A matches, they have not tasted defeat since and are the only team to have beaten Juve in the league this term.
A win against Roma would see Le Aquile keep pace with the league leaders, with Lazio also just two points behind second-placed Inter Milan.
Roma Serie A form: DWWLLW
Roma recent form (all competitions): WLLWWL
Lazio Serie A form: WWWWWW
Lazio recent form (all competitions): WWWWWL
Roma possible starting lineup:
Lopez; Santon, Mancini, Smalling, Spinazzola; Veretout, Cristante, Pellegrini; Under, Dzeko, Pastore
Lazio possible starting lineup:
Strakosha; Patric, Acerbi, Radu; Lazzari, Milinkovic-Savic, Leiva, Alberto, Lulic; Immobile, Correa
We say: Roma 1-2 Lazio
Lazio have been irresistible of late, scoring goals for fun and beating all teams in sight. With Roma going through a tricky spell, expect Lazio to compound Paulo Fonseca's issues with a third defeat since the start of the new year.