Roma coach Rudi Garcia has opted to leave out Francesco Totti and Adem Ljajic from his starting XI for the Serie A trip to Sampdoria.
There is also only a spot on the bench for Alessandro Florenzi, which means that Roma's attack comprises of Marquinho, Marco Borriello and Gervinho.
For the hosting Samp, Eder remains out so Manolo Gabbiadini and Gianluca Sansone start up front.
Sampdoria: Da Costa; Mustafi, Gastaldello, Palombo, Costa; De Silvestri, Kristicic, Obiang, Regini; Sansone, Gabbiadini
Roma: De Sanctis; Maicon, Benatia, Castan, Balzaretti; Pjanic, De Rossi, Strootman; Marquinho, Borriello, Gervinho