West Bromwich Albion can mirror last season's strong start with a victory in their opening Premier League fixture, while Southampton's aim is to retain their top-flight status for a second campaign in a row.
The Baggies finished eighth last season under head coach Steve Clarke, who has added former Chelsea striker Nicolas Anelka, Goran Popov and Diego Lugano to the squad, while the club are awaiting news on Scott Sinclair's potential arrival from Manchester City.
Anelka is likely to start up front alongside Shane Long at The Hawthorns, while Youssouf Mulumbu and Claudio Yacob could hold the midfield line.
Mauricio Pochettino's Southampton side will head into their first game with Luke Shaw and Nathaniel Clyne both doubtful, but Dejan Lovren is expected to make his Premier League debut for the Saints.
Rickie Lambert is likely to be chosen by Pochettino to lead the attack after scoring on his England debut in the Three Lions' 3-2 win over Scotland at Wembley on Wednesday night.
Possible lineups
West Bromwich Albion: Foster; Ridgewell, Olsson, McAuley, Jones; Brunt, Mulumbu, Yacob, Morrison; Anelka, Long
Southampton: Boruc; Shaw, Yoshida, Lovren, Clyne; Lallana, Wanyama, Schneiderlin, Cork, Ramirez; Lambert
Sports Mole says: 2-0