Goals from Fabio Quagliarella, Maxi Lopez and Matteo Darmian were enough to cancel out responding efforts from Andoni Iraola and Oscar de Marcos, ensuring that Giampiero Ventura's men sealed progression into the last 16.
Elsewhere, Club Brugge moved into the next round with consummate ease as they grabbed a 3-0 victory at home to Aalborg BK, with goals from Victor Vazquez, Obbi Oulare and Boli Bolingoli-Mbombo completing a 6-1 demolition.
Napoli also secured safe passage without having too much work to do at home to visiting Trabzonspor, as Jonathan de Guzman gave them a 1-0 victory on the night resulting in a resounding 5-0 overall victory.
Finally, Roma had to produce some heroics of their own to keep hosts Feyenoord at bay, with the Italian side claiming a 2-1 victory on the road courtesy of Adem Ljajic and Gervinho, who helped to setup a 3-2 aggregate win for the Wolves.
Results in full: Athletic Bilbao 2-3 Torino, Club Brugge 3-0 Aalborg BK, Everton 3-1 Young Boys, Feyenoord 1-2 Roma, Napoli 1-0 Trabzonspor, Olympiacos 2-2 Dnipro Dnipropetrovsk, Sporting Lisbon 0-0 Wolfsburg