Atletico Madrid head coach Diego Simeone has been handed an untimely late blow over Memphis Depay's fitness for Wednesday's Champions League quarter-final first leg with Borussia Dortmund at the Wanda Metropolitano.
The Dutchman - scorer of his side's second in their dramatic last-16 second-leg win over Inter Milan - could not complete the full training session on Saturday due to a knock, and he has now been ruled out of the first leg.
Depay is one of three concerns for Simeone to take into account for Wednesday, as Mario Hermoso is struggling with a thigh issue and will miss out too, while Thomas Lemar is on the mend from a ruptured Achilles.
With Depay confined to the medical bay, Antoine Griezmann and Alvaro Morata are primed to link arms in Simeone's two-man strikeforce, and the hosts' three-man midfield also picks itself.
Indeed, Rodrigo de Paul, Koke and Marcos Llorente are expected to line up in the engine room, with Nahuel Molina and Samuel Lino operating as the widest men in the 3-5-2 system.
Former Borussia Dortmund man Axel Witsel will likely reunite with his old employers as part of Jan Oblak's rigid defensive shield, which should also comprise Jose Gimenez and Reinildo, although Cesar Azpilicueta is a viable alternative.
Atletico Madrid possible starting lineup:
Oblak; Witsel, Gimenez, Reinildo; Molina, Llorente, Koke, De Paul, Lino; Griezmann, Morata
> Click here to see how Dortmund could line up for the first leg
