The January signing from Liverpool made his Blaugrana debut as a substitute in the midweek 2-0 win over Espanyol in the Copa del Rey.
Ernesto Valverde has now opted to draft Coutinho into the starting XI alongside Lionel Messi and Luis Suarez for the Brazilian's first Barca appearance in the Spanish top flight, which sees the Catalans up against the struggling Basques.
Lucas Digne is picked at left-back as Jordi Alba starts on the bench, while Ivan Rakitic is selected ahead of Sergio Busquets in central midfield and Ruben Semedo is given the nod over Sergi Roberto at right-back.
Barcelona: Ter Stegen; Semedo, Pique, Umtiti, Digne; Rakitic, Iniesta, Paulinho; Messi, Suarez, Coutinho
Subs: Cillessen, Sergio, Alcacer, Alba, Roberto, Vidal, Mina
Alaves: Pacheco; Duarte, Laguardia, Maripan, Ruano; Mubarak, Medran, Pedraza, Gomez; Sobrino, Guidetti
Subs: Sivera, Martin, Vigaray, Pedraza, Munir, Dieguez, Demirovic
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