The Bundesliga leaders were thrashed 5-1 in the reverse fixture earlier this season in what proved to be the nadir of their campaign.
Bayern head into Saturday's clash with Frankfurt four points clear at the summit, though there is the small matter of next week's showdown with second-place Borussia Dortmund.
Here, Sports Mole looks at how the hosts could line up against Frankfurt.
Bayern are expected to be without Philippe Coutinho and Corentin Tolisso for the rest of 2019-20, with both players having undergone surgery during the two-month hiatus.
The prolonged break turned out to be a good thing for Robert Lewandowski, though, as the division's leading goalscorer has fully recovered from a knee injury.
Lewandowski scored from the spot in last week's 2-0 win over Union Berlin to bring up his 40th goal of the campaign in all competitions.
Despite the huge Der Klassiker with Dortmund coming just three days after this game, Flick is unlikely to tinker too much with a winning formula.
Both players were introduced as second-half subs last time out, as was Michael Cuisance, and they are in line for recalls if Flick does indeed feel the need to rotate.