The in-form hosts made a winning return to action last week to remain four points clear at the top, while Frankfurt fell to another defeat and are not yet safe from the drop.
Bayern may not have been at their best against Union Berlin, but that is entirely understandable given the two-month break between matches owing to the coronavirus pandemic.
Bayern were down in seventh after 14 matches, but they have slowly climbed the division and now hold a four-point advantage on closest challengers Borussia Dortmund.
Should everything go to plan this weekend, with Dortmund taking on Wolfsburg elsewhere on Saturday, there will be plenty riding on next week's Der Klassiker.
Flick will not need telling that his side cannot afford to take their eye off the ball, but the form book certainly suggests that this match will only end one way.
While Bayern have won 11 of their last 12 matches in all competitions, drawing the other, Frankfurt have lost their last three games, each in a different competition.
Adi Hutter's side have slipped from ninth to 13th in the space of five games and are only five points above the relegation playoff spot.
To make matters worse for Frankfurt, they have the worst away record in the Bundesliga this term and have lost each of their last 10 league trips to the Allianz Arena.
However, the Eagles did famously beat Bayern 5-1 in the reverse fixture earlier this season - a result that led to Kovac's sacking, and ultimately the Bavarians' turnaround.
Revenge will be on the cards for the hosts on Saturday, then, but more important than that will be maintaining their healthy lead at the top ahead of the much-anticipated Der Klassiker.
Bayern Munich's Bundesliga form: DWWWWW
Bayern Munich's form (all competitions): WWWWWW
Eintracht Frankfurt's Bundesliga form: DWLLLL
Eintracht Frankfurt's form (all competitions): LDWLLL
Lewandowski used the two-month hiatus to overcome a knee injury and looked sharp on his return to action last week, so the division's leading scorer will likely retain his place.
Bayern Munich possible starting lineup:
Neuer; Pavard, Boateng, Alaba, Davies; Kimmich, Thiago; Muller, Goretzka, Gnabry; Lewandowski
Eintracht Frankfurt possible starting lineup:
Trapp; Toure, Abraham, Hinteregger, N'Dicka; Ilsanker, Rode; Chandler, Kamada, Kostic; Dost
We say: Bayern Munich 3-0 Eintracht Frankfurt
Bayern have won five Bundesliga games in a row, whereas Frankfurt have lost each of their last four. The Eagles may have come out on top in the reverse fixture, but they are without a point in 10 visits to the Allianz Arena and we are not expecting that run to end this weekend.